Systemic Lupus Erythematosus complicated by Neuromyelitis Optica (Devic’s Syndrome): case series from a single paediatric rheumatology centre
نویسندگان
چکیده
Results A total of 210 (161 females, 49 males) SLE patients were indentified, 39 of which had manifestations of potential CNS involvement and underwent imaging of their CNS including spinal cord. Three were indentified with probable Devic syndrome, which was confirmed in two (0.9%). Both patients were adolescent females and of Caucasian origin. In one patient NMO was the first manifestation of SLE. In the other NMO developed three years following diagnosis of SLE. They both presented with deterioration of visual acuity, localized spine tenderness and malaise. NMO was confirmed based on MRI findings and the presence of raised Aquaporin-4 IgG antibodies in the plasma. On both occasions NMO had a relapsing course and interestingly NMO relapses coincided with SLE disease flare-up, which responded to treatment simultaneously. The patient with ongoing SLE had a more severe course and required more intensive immunosuppressive treatment. Both patients developed depression following diagnosis of NMO.
منابع مشابه
Systemic Lupus Erythematosus (SLE) Complicated by Neuromyelitis Optica (NMO – Devic’s Disease): Clinic-Pathological Report and Review of the Literature
Neuromyelitis optica (NMO) is usually a relapsing demyelinating disease of the central nervous system associated with optic neuritis, transverse myelitis involving three or more contiguous spinal cord segments, and seropositivity for NMO-IgG antibody. NMO is often mistaken for multiple sclerosis and there are relatively sporadic publications about NMO and overlapping systemic or organ-specific ...
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